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After imaging studies were complete, monkeys were implanted with indwelling intravenous catheters and self-administered cocaine 0. Acquisition of cocaine reinforcement occurred when response rates were significantly higher than when saline was self-administered. Dominant female monkeys acquired cocaine reinforcement at significantly lower doses than subordinate monkeys. These data indicate that the social environment profoundly affects the DA system, but does so in ways that have different functional consequences for females than males. Although several novel avenues are being considered, at present there are no FDA-approved treatments for cocaine addiction 3 — 4.
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